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3-Bromopyruvic acid
CAS No. 1113-59-3
3-Bromopyruvic acid ( Bromopyruvic acid | Hexokinase II Inhibitor II 3-BP )
产品货号. M20515 CAS No. 1113-59-3
3-Bromopyruvic Acid 是一种己糖激酶 II 抑制剂，抑制糖酵解/己糖激酶的 Ki 值为 2.4 mM。是肿瘤细胞能量代谢的抑制剂和铂类化合物的化学增效剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 500MG | ￥332 | 有现货 |
|
| 1G | ￥389 | 有现货 |
|
生物学信息
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产品名称3-Bromopyruvic acid
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述3-Bromopyruvic Acid 是一种己糖激酶 II 抑制剂，抑制糖酵解/己糖激酶的 Ki 值为 2.4 mM。是肿瘤细胞能量代谢的抑制剂和铂类化合物的化学增效剂。
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产品描述3-Bromopyruvic acid is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.
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体外实验Cell Viability Assay Cell Line:MCF-7 and MDA-MB-231 cells Concentration:40, 80, 160 or 320 μM Incubation Time:24 hours Result:3-Bromopyruvate (80 and 160 μmol/l) and TRAIL (400 ng/ml) significantly inhibited cell viability.
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体内实验Animal Model:Female nude mice (BALB/c; 4-5-weeks old and 18-20 g)Dosage:8 mg/kg Administration:I.p.; every 4 days for 28 days Result:Showed antitumor efficacy in tumor xenografts.
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同义词Bromopyruvic acid | Hexokinase II Inhibitor II 3-BP
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通路Others
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靶点Other Targets
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受体hexokinase II
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研究领域Cancer
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适应症antineoplastic
化学信息
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CAS Number1113-59-3
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分子量166.96
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分子式C3H3BrO3
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纯度>98% (HPLC)
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溶解度H2O:32 mg/mL (191.66 mM)
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SMILESOC(=O)C(=O)CBr
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Leng X Peng J Yu X et al. 3-Bromopyruvic Acid A Hexokinase II Inhibitor is an Effective Antitumor Agent on the Hepatoma Cells : in vitro and in vivo Findings[J]. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents) 2014 14(5):-.
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